UC DAVIS GENERAL CATALOG--Programs and Courses

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Biological Sciences: Microbiology

Stephen C. Kowalczykowski, Ph.D., Chairperson of the Section
Section Office, 156 Hutchison Hall (530-752-0262)
World Wide Web: http://www-mic.ucdavis.edu/micro

Faculty

Primary Section Members

Stanley W. Artz, Ph.D., Professor
Paul Baumann, Ph.D., Professor
Wolf-Dietrich Heyer, Ph.D., Associate Professor
Michele M. Igo, Ph.D., Associate Professor
Daniel J. Klionsky, Ph.D., Professor
Stephen C. Kowalczykowski, Ph.D., Professor
JaRue S. Manning, Ph.D., Professor
John C. Meeks, Ph.D., Professor
Douglas C. Nelson, Ph.D., Professor
Martin L. Privalsky, Ph.D., Professor
Kazuhiro Shiozaki, Ph.D., Assistant Professor
Mitchell H. Singer, Ph.D., Assistant Professor
Valley J. Stewart, Ph.D., Professor
Merna R. Villarejo, Ph.D., Professor
Mark L. Wheelis, Ph.D., Senior Lecturer

Secondary Section Members

Jodi Nunnari, Ph.D., Assistant Professor
Irwin H. Segel, Ph.D., Professor

Emeriti Faculty

Robert E. Hungate, Ph.D., Professor Emeritus
John L. Ingraham, Ph.D., Professor Emeritus
Allen G. Marr, Ph.D., Professor Emeritus
Herman J. Phaff, Ph.D., Professor Emeritus
David Pratt, Ph.D., Professor Emeritus


View the major in Microbiology.


Courses in Microbiology (MIC)

Upper Division Courses Graduate Courses Professional Courses

*Course not offered this academic year.

General Education (GE) credit: ArtHum = Arts and Humanities; SciEng = Science and Engineering; SocSci = Social Sciences; Div = Social-Cultural Diversity; Wrt = Writing Experience. Select this link to information on the General Education requirement.

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Lower Division Courses

10. Natural History of Infectious Diseases (4) II. Manning

Lecture--3 hours; discussion--1 hour. Topics in the natural history of infectious diseases principally affecting humans. Introduction to infectious microbial agents, ecology, epidemiology, and induction of disease. Focus on diseases of a contemporary nature. Designed for students not majoring in the biological sciences. GE credit: SciEng, Wrt.

98. Directed Group Study (1-5) I, II, III. The Staff (Chairperson in charge)

Prerequisite: consent of instructor. Primarily for lower division students. (P/NP grading only.)

Upper Division Courses

102. General Bacteriology (4) I, II. Artz; III. Baumann

Lecture--4 hours. Prerequisite: Biological Sciences 1A and Chemistry 8B or Chemistry 118B (may be taken concurrently). Survey of the biology of bacteria and viruses, including bacterial structure, metabolism, physiology, genetics, and evolution; viral structure and replication; the role of bacteria in global element cycles; and the role of microbes in infectious disease.

102L. General Bacteriology Laboratory (2) I, II. Artz; III. Wheelis

Laboratory--6 hours. Prerequisite: course 102 (may be taken concurrently) and consent of instructor. Introduction to principles and laboratory methods employed in working with microorganisms. For students planning to continue study of microbiology, or use microorganisms as tools for study of genetics and biochemistry.

105. Bacterial Diversity (5) II. Nelson, Wheelis

Lecture--3 hours; laboratory--6 hours. Prerequisite: courses 102, 102L, Biological Sciences 102 and consent of instructor; Biological Sciences 103 recommended. Survey of the major groups of bacteria emphasizing diversity of energy metabolism, morphology and natural history. Includes methods for determination of evolutionary relationships among groups. Isolation and characterization of bacterial strains from various habitats.

*110. Bacteriology of Insects (3) II. Baumann

Lecture--3 hours. Prerequisite: course 102; Biological Sciences 102. Physiological basis of pathogenic and symbiotic associations between procaryotes and insects. Taxonomy, physiology, pathogenesis, and molecular biology of insect pathogens. Insect immunity. Nutritional associations between microorganisms and insects. Pertinent entomological background information will be included.

120. Microbial Ecology (3) III. Meeks

Lecture--3 hours. Prerequisite: course 105, Biological Sciences 102. Interactions between non-pathogenic microorganisms and their environment, emphasizing physiological and metabolic characteristics of various groups and their adaptation to and modification of specific habitats.

120L. Microbial Ecology Laboratory (2) III. Meeks

Laboratory--6 hours; one optional overnight weekend field trip. Prerequisite: course 120 (may be taken concurrently); consent of instructor. Study of prokaryotic microorganisms from certain habitats. One-half of laboratory effort will consist of organized experiments on ecologically important microbial activities. For remaining one-half, research projects will be done on student selected specific habitats of microorganisms. Limited enrollment.

140. Bacterial Physiology (3) I. Singer

Lecture--3 hours. Prerequisite: Biological Sciences 101, 102, 103 (may be taken concurrently); course 102 recommended (may be taken concurrently). Fundamentals of bacterial growth and bacterial responses to environmental stresses. Topics will include carbon and nitrogen regulation, growth rate control, post-exponential growth, and motility and chemotaxis. Not open for credit to students who have completed course 130A.

150. Bacterial Genetics (3) II. Stewart

Lecture--3 hours. Prerequisite: Biological Sciences 101 and 102; course 102 (may be taken concurrently) recommended. Fundamentals of bacterial and phage genetics. Topics will include generating mutations, phage genetics, classical bacterial genetics, molecular techniques to generate mutations and physical mapping techniques. Not open for credit to students who have completed course 130A.

155L. Bacteriology Physiology Laboratory

(3) III. Artz, Wheelis

Laboratory--9 hours. Prerequisite: course 140 or 150; course 102L; consent of instructor. Physiology and genetics of bacteria. Isolation and characterization of mutant strains. Mapping of mutations by conjugation and transduction studies of control of enzyme synthesis by induction, repression, and catabolite repression. Former course 130L. Not open for credit to students who have taken course 130L.

*160. Bacterial Regulatory Mechanisms

(3) III. Kowalczykowski, Artz

Lecture--3 hours. Prerequisite: course 140 or 150 recommended. Fundamentals of bacterial regulatory mechanisms. Topics will include control of DNA, RNA, and protein synthesis, global regulatory mechanisms, recombination, DNA repair systems, and cell cycle control with emphasis on bacterial systems. Not open for credit to students who have taken course 130B. (Former course 130B.)

162. General Virology (4) III. Manning, Falk (Plant Pathology)

Lecture--4 hours. Prerequisite: Biological Sciences 1A, 102. Integrated presentation of the nature of animal, bacterial, and plant viruses, including their structure, replication and genetics.

190C. Undergraduate Research Conference (1) I, II, III. The Staff (Chairperson in charge)

Discussion--1 hour. Prerequisite: upper division standing and consent of instructor, course 199 concurrently. Presentation and critical discussion of staff research activities: designed for advanced undergraduate students. May be repeated for credit. (P/NP grading only.)

192. Internship (1-12) I, II, III. The Staff

Internship--3-36 hours. Technical and/or professional experience on or off campus. Supervised by a member of the Microbiology Section faculty. (P/NP grading only.)

194H. Microbiology Honors Research (2) I, II, III. The Staff

Independent study--6 hours. Prerequisite: senior standing; eligibility for college honors; completion of six units of 199 in microbiology; consent of section. Continuation of an individual microbiological research project culminating in writing of a senior thesis under a faculty director. (P/NP grading only.)

197T. Tutoring in Microbiology (1-5) I, II, III. The Staff (Chairperson in charge)

Tutoring--1-5 hours. Prerequisite: course 102L and 18 upper division units in Microbiology; consent of chairperson. Assist in undergraduate laboratory courses supervised by teaching assistants or faculty; in discussion sections supervised by faculty; and staffing "drop-in" offices for individual help. (P/NP grading only.)

198. Directed Group Study (1-5) I, II, III. The Staff (Chairperson in charge)

Prerequisite: consent of instructor. (P/NP grading only.)

199. Special Study for Advanced Undergraduates (1-5) I, II, III. The Staff (Chairperson in charge)

Prerequisite: consent of instructor. (P/NP grading only.)

Graduate Courses

200A-*200B-*200C. Microbiology for First-Year Graduate Students (3-3-3) I-II-III. The Staff (Graduate Group chairperson in charge)

Lecture--3 hours. Prerequisite: first-year graduate standing with interest in microbiology. A survey of general microbiology at the graduate level.

201L. Advanced Microbiology Laboratory Rotations (5) I, II. The Staff

Laboratory--15 hours. Prerequisite: course 200A (may be taken concurrently). Two five-week assignments in microbiology research laboratories. Individual research problems with emphasis on methodological/procedural experience and experimental
design. May be repeated twice for credit.

210. Molecular Mechanisms in Microbial Pathogenesis (3) III. Manning, Hirsh (Pathology, Microbiology and Immunology)

Lecture--3 hours. Prerequisite: course 105 or Veterinary Microbiology 127 and course 162 or Veterinary Microbiology 128 or the equivalent. Study of the molecular mechanisms involved in cytopathogenesis of higher eukaryotic organisms. Emphasis on the alteration or inhibition of cellular metabolism and function by bacteria and animal viruses.

215. Recombinant DNA (3) I. Privalsky

Lecture--3 hours. Prerequisite: Biological Sciences 101, 102, 103 or the equivalent. Application of recombinant DNA technology to modern problems in biology, biochemistry, and genetics, emphasizing molecular cloning strategies, choice of vectors, preparation of insert DNA, and selection procedures.

250. Biology of Yeasts (5) II. Bisson (Viticulture and Enology)

Lecture--3 hours; discussion--2 hours. Prerequisite: Biological Sciences 102, 103; course 102, 102L; course 215 recommended. Survey of the genetics, physiology, metabolism, regulatory mechanisms, structure, cell biology, ecology and diversity of yeasts and related organisms. Offered in alternate years.

*260. Bacterial Genetic Regulatory Mechanisms (3) I. Artz

Lecture/discussion--3 hours. Prerequisite: general knowledge of nucleic acid biochemistry and bacterial genetics. Analysis at the molecular level of genetic regulation in selected bacterial systems. Specific
systems discussed will include the following types of regulation: control of transcription initiation and termination; translational controls; tRNA modification effects; autoregulation; control circuits in bacterial viruses; supercontrols. Offered in alternate years.

262. Advanced General and Molecular Virology (3) III. Manning, Luciw (Medical Pathology), Bruening (Plant Pathology)

Lecture--3 hours. Prerequisite: graduate standing. Advanced integrated presentation of animal, bacterial, and plant viruses, including their structure, modes of regulation, expression and replication, and effects on host cells and organisms.

263. Principles of Protein-Nucleic Acid Interactions (3) III. Kowalczykowski

Lecture--3 hours. Prerequisite: advanced graduate standing and completion of one year of basic graduate course work in biochemistry, biophysics, chemistry, genetics, microbiology, or molecular biology. Physical basis of protein-nucleic acid interaction. Topics include nucleic acid recognition by proteins, thermodynamics of protein-nucleic acid stability, and kinetics of binding process for both non-specific and sequence-specific nucleic acid binding proteins. Emphasis on systems that represent paradigms in protein-nucleic acid interactions. Offered in alternate years.

274. Seminar in Genetic Recombination (1) I, II, III. Kowalczykowski

Seminar--1 hour. Prerequisite: graduate standing; consent of instructor. Biochemical and genetic aspects of genetic recombination in prokaryotes and eukaryotes. Mechanisms of recombination and biochemical and genetic characteristics of recombination proteins. Proteins include DNA strand exchange, DNA helicases, and Holliday junction resolving proteins. May be repeated for credit. (S/U grading only.)

290C. Advanced Research Conference (1) I, II, III. The Staff (Chairperson in charge)

Discussion/conference--1 hour. Prerequisite: graduate standing and/or consent of instructor. Presentation and critical discussion of staff research activities. Designed for advanced graduate students. May be repeated for credit. (S/U grading only.)

291. Selected Topics in Microbiology (1) I, II, III. Singer

Seminar--1 hour. Prerequisite: graduate standing and consent of instructor. Current progress in microbiology and cellular and molecular biology. May be repeated for credit. (S/U grading only.)

292. Seminar in Bacterial Physiology, Genetics and Virology (1) I, II, III. The Staff

Seminar--1 hour. Prerequisite: consent of instructor. Review and discussion of current literature and developments in bacterial physiology, genetics, and virology with presentations by individual students. (S/U grading only.)

293. Seminar in Protein Sorting (1) I, II. Klionsky

Seminar--1 hour. Prerequisite: consent of instructor. Current research papers on the topics of organelle biogenesis, protein sorting and secretion. May be repeated for credit. (S/U grading only.)

*296. Seminar in Animal Virology (1) II. Manning

Seminar--1 hour. Prerequisite: consent of instructor. Discussion of current topics in animal virology. (Same course as Pathology, Microbiology and Immunology 292A.) May be repeated for credit. (S/U grading only.)

298. Group Study (1-5) I, II, III. The Staff (Chairperson in charge)

Prerequisite: consent of instructor. (S/U grading only.)

299. Research (1-12) I, II, III. The Staff (Chairperson in charge)

(S/U grading only.)

Professional Course

396. Teaching Assistant Training Practicum
(1-4) I, II, III. The Staff (Chairperson in charge)

Prerequisite: graduate standing. May be repeated for credit. (S/U grading only.)


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UC Davis 1999-2000 Online General Catalog. Posted July 30, 1999.
catalog-comment@ucdavis.edu
Molly Theodossy, Keitha Hunter and Barbara Anderson, Editors

We welcome your comments.